CYP1B1-IN-8

CYP1B1-IN-8

• UNSPSC Description: CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 × 10–5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel (HY-B0015), and inhibits cell migration and invasion[1].
• Target Antigen: Cytochrome P450
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cyp1b1-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: IC1=CC=C(C2=NC3=CC=CC=C3C(NCC)=N2)C=C1.Cl
• Molecular Weight: 411.67
• References & Citations: [1]Yang M, et al. Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells. J Med Chem. 2024 Apr 11;67(7):5883-5901.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported