CYP1B1-IN-8

• UNSPSC Description:

  CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 × 10–5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel (HY-B0015), and inhibits cell migration and invasion[1].

• Target Antigen:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cyp1b1-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  IC1=CC=C(C2=NC3=CC=CC=C3C(NCC)=N2)C=C1.Cl

• Molecular Weight:

  411.67

• References & Citations:

  [1]Yang M, et al. Design of Novel 2-Phenylquinazolin-4-amines as Selective CYP1B1 Inhibitors for Overcoming Paclitaxel Resistance in A549 Cells. J Med Chem. 2024 Apr 11;67(7):5883-5901.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported