CYP1B1-IN-3

• UNSPSC Description:

  CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1].

• Target Antigen:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cyp1b1-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC(NC2=NC(C3=NC(C4=C(C=CC=C4)F)=CS3)=CS2)=CC(OC)=C1

• Molecular Weight:

  413.49

• References & Citations:

  [1]Mao J, et al. Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells. J Med Chem. 2022 Dec 22;65(24):16451-16480.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2872575-51-2