CYP1B1-IN-3

CYP1B1-IN-3

• CAS Number: 2872575-51-2
• UNSPSC Description: CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1].
• Target Antigen: Cytochrome P450
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cyp1b1-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC(NC2=NC(C3=NC(C4=C(C=CC=C4)F)=CS3)=CS2)=CC(OC)=C1
• Molecular Weight: 413.49
• References & Citations: [1]Mao J, et al. Structure-Based Drug Design and Synthesis of Novel N-Aryl-2,4-bithiazole-2-amine CYP1B1-Selective Inhibitors in Overcoming Taxol Resistance in A549 Cells. J Med Chem. 2022 Dec 22;65(24):16451-16480.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported