CYP1B1-IN-7

• UNSPSC Description:

  CYP1B1-IN-7 (compound 2a) is a selective inhibitor of CYP1B1 (IC50: 75 nM). CYP1B1-IN-7 also reverses resistance (IC50: 29 μM) and exhibits cytotoxicity in the CYP1B1-overexpressing MCF-7 cell line that is resistant to Docetaxel (HY-B0011)[1].

• Target Antigen:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/cyp1b1-in-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC=C2C=CC=CC2=C1)/C=C/C3=CC=C(Cl)C=C3

• Molecular Weight:

  292.76

• References & Citations:

  [1]Raju B, et al. Scaffold hopping for designing of potent and selective CYP1B1 inhibitors to overcome docetaxel resistance: synthesis and evaluation. J Biomol Struct Dyn. 2024 Feb 14:1-19.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  No Development Reported

• CAS Number:

  52601-58-8