Human Recombinant STING R232 variant (N242A mutant)

• Short Description:

  Catalog Number: B2017658 (50 µg)_x000D_ The STING R232 variant (N242A mutant) is a laboratory-engineered version of the protein used in research to study immune response effects and signaling pathways. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Description:

  Human Recombinant STING R232 variant (N242A mutant)_x000D_ Catalog number: B2017658_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 28.7 kDa_x000D_ Supplied as: SOLUTION_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, MITA, Mitochondrial Mediator of IRF3 Activation, MPYS, Stimulator of Interferon Genes, Stimulator of Interferon Response cGAMP Interactor 1, STING1, N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner, TMEM173, Transmembrane Protein 173_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Froechlich G, Finizio A, Napolano A, Amiranda S, De Chiara A, Pagano P, Mallardo M, Leoni G, Zambrano N, Sasso E. The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties Sci Rep. 2023 Nov 9;13(1):19541._x000D_ 2: Patel S, Jin L. TMEM173 variants and potential importance to human biology and disease Genes Immun. 2019 Jan;20(1):82-89._x000D_ 3: Chang PW, Wang JY, Wang WP, Huang WC, Wu MH, Song JS, Chen LY, Tung CW, Chi YH, Ueng SH. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors Bioorg Med Chem. 2023 Nov 15;95:117502._x000D_ 4: Jekle A, Thatikonda SK, Jaisinghani R, Ren S, Kinkade A, Stevens SK, Stoycheva A, Rajwanshi VK, Williams C, Deval J, Mukherjee S, Zhang Q, Chanda S, Smith DB, Blatt LM, Symons JA, Gonzalvez F, Beigelman L. Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models Int J Mol Sci. 2023 Nov 13;24(22):16274._x000D_ 5: Aliakbar Tehrani Z, Rulíšek L, ÄŒerný J. Molecular dynamics simulations provide structural insight into binding of cyclic dinucleotides to human STING protein J Biomol Struct Dyn. 2022;40(20):10250-10264._x000D_ 6: Wang Z, Zhao C, Wang C, Zhang H, Ma D, Zhang Q, Wen X, Li L, Xi Z. Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants Bioorg Med Chem. 2021 Jan 1;29:115899._x000D_ 7: Lukashevich OV, Cherepanova NA, Jurkovska RZ, Jeltsch A, Gromova ES. Conserved motif VIII of murine DNA methyltransferase Dnmt3a is essential for methylation activity BMC Biochem. 2016 Mar 22;17:7._x000D_ 8: Darii MV, Cherepanova NA, Subach OM, Kirsanova OV, Raskó T, Slaska-Kiss K, Kiss A, Deville-Bonne D, Reboud-Ravaux M, Gromova ES. Mutational analysis of the CG recognizing DNA methyltransferase SssI: insight into enzyme-DNA interactions Biochim Biophys Acta. 2009 Nov;1794(11):1654-62._x000D_ 9: Chamovitz DA, Glickman M. The COP9 signalosome Curr Biol. 2002 Apr 2;12(7):R232._x000D_ 10: Straka H, Simmers J, Chagnaud BP. A New Perspective on Predictive Motor Signaling Curr Biol. 2018 Mar 5;28(5):R232-R243. _x000D_ _x000D_ Products Related to Human Recombinant STING R232 variant (N242A mutant) can be found at Proteins

• CAS Number:

  9000-83-3

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5