Human Recombinant PARP1

• Description:

  Human Recombinant PARP1 _x000D_ Catalog number: B2016984_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 139 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: ADP-ribose Transferase 1, ADPRT, PARP1, PARP-1, NAD+ADP-ribosyltransferase 1, Poly(ADP-ribose) Polymerase 1, Poly(ADP-ribosyl)transferase_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: de Lange T. Shelterin-Mediated Telomere Protection Annu Rev Genet. 2018 Nov 23;52:223-247._x000D_ 2: Liu H, Zhang H, Wu X, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R, Jungblut P, Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, Chen J, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F, Yan D, Kaufmann SHE, Chen C, Mao Z, Ge B. Nuclear cGAS suppresses DNA repair and promotes tumorigenesis Nature. 2018 Nov;563(7729):131-136._x000D_ 3: Murai J, Huang SY, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S, Pommier Y. Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors Cancer Res. 2012 Nov 1;72(21):5588-99._x000D_ 4: Murai J, Pommier Y. BRCAness, Homologous Recombination Deficiencies, and Synthetic Lethality Cancer Res. 2023 Apr 14;83(8):1173-1174._x000D_ 5: D'Andrea AD. Mechanisms of PARP inhibitor sensitivity and resistance DNA Repair (Amst). 2018 Nov;71:172-176._x000D_ 6: Noordermeer SM, van Attikum H. PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells Trends Cell Biol. 2019 Oct;29(10):820-834._x000D_ 7: Krastev DB, Li S, Sun Y, Wicks AJ, Hoslett G, Weekes D, Badder LM, Knight EG, Marlow R, Pardo MC, Yu L, Talele TT, Bartek J, Choudhary JS, Pommier Y, Pettitt SJ, Tutt ANJ, Ramadan K, Lord CJ. The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin Nat Cell Biol. 2022 Jan;24(1):62-73._x000D_ 8: Zada D, Sela Y, Matosevich N, Monsonego A, Lerer-Goldshtein T, Nir Y, Appelbaum L. Parp1 promotes sleep, which enhances DNA repair in neurons Mol Cell. 2021 Dec 16;81(24):4979-4993.e7._x000D_ 9: Bonfiglio JJ, Leidecker O, Dauben H, Longarini EJ, Colby T, San Segundo-Acosta P, Perez KA, Matic I. An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation Cell. 2020 Nov 12;183(4):1086-1102.e23._x000D_ 10: Kim C, Chen C, Yu Y. Avoid the trap: Targeting PARP1 beyond human malignancy Cell Chem Biol. 2021 Apr 15;28(4):456-462. _x000D_ _x000D_ Products Related to Human Recombinant PARP1 can be found at Proteins

• Short Description:

  Catalog Number: B2016984 (10 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3