STING (TMEM173) (NM_198282) Human Recombinant Protein

• Background:

  This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

• Synonyms:

  ERIS; hMITA; hSTING; MITA; MPYS; NET23; SAVI; STING; STING-beta; TMEM173

• Gene ID:

  340061

• UniProt:

  Q86WV6

• Accession Number mRNA:

  NM_198282

• Chromosomal Location:

  5q31.2

• Expression System:

  HEK293T

• Tag:

  C-Myc/DDK

• Related Pathways:

  Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

• Field of Research:

  Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway

• Concentration:

  >50 ug/mL as determined by microplate BCA method

• Purity:

  > 80% as determined by SDS-PAGE and Coomassie blue staining

• Form:

  Liquid

• Buffer:

  25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

• Molecular Weight:

  42 kDa

• Storage Conditions:

  Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

• Symbol:

  TMEM173

• Species:

  Human

• Protein ID:

  NP_938023

• Overview:

  Recombinant protein of human transmembrane protein 173 (TMEM173)

• Gene ID URL:

  https://www.ncbi.nlm.nih.gov/gene/340061

• Uniprot URL:

  https://www.uniprot.org/uniprot/Q86WV6

• Accession Number mRNA URL:

  https://www.ncbi.nlm.nih.gov/nuccore/NM_198282

• Protein ID Link:

  https://www.ncbi.nlm.nih.gov/nuccore/NP_938023