STING R232 variant (N242A mutant)

• Description:

  STING R232 variant (N242A mutant)_x000D_ Catalog number: B2016785_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 28.7 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, ,MITA, Mitochondrial Mediator of IRF3 Activation_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Patel S, Jin L. TMEM173 variants and potential importance to human biology and disease Genes Immun. 2019 Jan;20(1):82-89._x000D_ 2: Chang PW, Wang JY, Wang WP, Huang WC, Wu MH, Song JS, Chen LY, Tung CW, Chi YH, Ueng SH. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors Bioorg Med Chem. 2023 Nov 15;95:117502._x000D_ 3: Froechlich G, Finizio A, Napolano A, Amiranda S, De Chiara A, Pagano P, Mallardo M, Leoni G, Zambrano N, Sasso E. The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties Sci Rep. 2023 Nov 9;13(1):19541._x000D_ 4: Jekle A, Thatikonda SK, Jaisinghani R, Ren S, Kinkade A, Stevens SK, Stoycheva A, Rajwanshi VK, Williams C, Deval J, Mukherjee S, Zhang Q, Chanda S, Smith DB, Blatt LM, Symons JA, Gonzalvez F, Beigelman L. Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models Int J Mol Sci. 2023 Nov 13;24(22):16274._x000D_ 5: Wang Z, Zhao C, Wang C, Zhang H, Ma D, Zhang Q, Wen X, Li L, Xi Z. Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants Bioorg Med Chem. 2021 Jan 1;29:115899._x000D_ 6: Aliakbar Tehrani Z, Rulíšek L, Černý J. Molecular dynamics simulations provide structural insight into binding of cyclic dinucleotides to human STING protein J Biomol Struct Dyn. 2022;40(20):10250-10264._x000D_ 7: Aulanier A, Dambricourt L, Cayzac V, Stolowy N, Denis D, David T. Corneal hornet sting J Fr Ophtalmol. 2022 Nov;45(9):1108-1110._x000D_ 8: Mebs D. [Jellyfish sting injuries] Hautarzt. 2014 Oct;65(10):873-8._x000D_ 9: Rivara S, Ablasser A. COPA silences STING J Exp Med. 2020 Nov 2;217(11):e20201517._x000D_ 10: Boburka SM. Reducing the sting: Diagnosis and management of Hymenoptera venom allergy JAAPA. 2021 Aug 1;34(8):28-32. _x000D_ _x000D_ Products Related to STING R232 variant (N242A mutant) can be found at Proteins

• Short Description:

  Catalog Number: B2016785 (50 µg)

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height:

  0.5

• Height :

  0.5