STING R232 variant (N242A mutant)

• CAS Number:

  STING R232 variant (N242A mutant)_x000D_ Catalog number: B2016785_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 50 µg_x000D_ Molecular Weight or Concentration: 28.7 kDa_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: Endoplasmic Reticulum Interferon Stimulator, ERIS, Mediator of IRF3 Activation, ,MITA, Mitochondrial Mediator of IRF3 Activation_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Patel S, Jin L. TMEM173 variants and potential importance to human biology and disease Genes Immun. 2019 Jan;20(1):82-89._x000D_ 2: Chang PW, Wang JY, Wang WP, Huang WC, Wu MH, Song JS, Chen LY, Tung CW, Chi YH, Ueng SH. Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors Bioorg Med Chem. 2023 Nov 15;95:117502._x000D_ 3: Froechlich G, Finizio A, Napolano A, Amiranda S, De Chiara A, Pagano P, Mallardo M, Leoni G, Zambrano N, Sasso E. The common H232 STING allele shows impaired activities in DNA sensing, susceptibility to viral infection, and in monocyte cell function, while the HAQ variant possesses wild-type properties Sci Rep. 2023 Nov 9;13(1):19541._x000D_ 4: Jekle A, Thatikonda SK, Jaisinghani R, Ren S, Kinkade A, Stevens SK, Stoycheva A, Rajwanshi VK, Williams C, Deval J, Mukherjee S, Zhang Q, Chanda S, Smith DB, Blatt LM, Symons JA, Gonzalvez F, Beigelman L. Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models Int J Mol Sci. 2023 Nov 13;24(22):16274._x000D_ 5: Wang Z, Zhao C, Wang C, Zhang H, Ma D, Zhang Q, Wen X, Li L, Xi Z. Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants Bioorg Med Chem. 2021 Jan 1;29:115899._x000D_ 6: Aliakbar Tehrani Z, Rulíšek L, ÄŒerný J. Molecular dynamics simulations provide structural insight into binding of cyclic dinucleotides to human STING protein J Biomol Struct Dyn. 2022;40(20):10250-10264._x000D_ 7: Aulanier A, Dambricourt L, Cayzac V, Stolowy N, Denis D, David T. Corneal hornet sting J Fr Ophtalmol. 2022 Nov;45(9):1108-1110._x000D_ 8: Mebs D. [Jellyfish sting injuries] Hautarzt. 2014 Oct;65(10):873-8._x000D_ 9: Rivara S, Ablasser A. COPA silences STING J Exp Med. 2020 Nov 2;217(11):e20201517._x000D_ 10: Boburka SM. Reducing the sting: Diagnosis and management of Hymenoptera venom allergy JAAPA. 2021 Aug 1;34(8):28-32. _x000D_ _x000D_ Products Related to STING R232 variant (N242A mutant) can be found at Proteins

• Short Description:

  Catalog Number: B2016785 (50 µg)_x000D_ STING R232 variant (N242A mutant) is a high quality specific mutation in the STING protein, which is also known as stimulator of interferon genes. This mutation involves changing the amino acid at position 242 from asparagine (N) to alanine (A). STING is a key regulator of the innate immune response, particularly in response to viral infections and other pathogens. Mutations in STING can affect its function and signaling pathways, potentially leading to altered immune responses. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5