Recombinant STING Monoclonal Antibody

• Background:

  STING has several transmembrane domains, and is expressed in a variety of endothelial cells, epithelial cells and hematopoietic liver cells. STING participates in the DNA-mediated innate immune response. Non-CpG double-stranded DNA from viruses or bacteria binds to cGAS protein and is catalyzed to the second messenger cGAMP; then the dimerized STING binds to cGAMP and undergoes conformational changes. Through the autophagsome and the endoplasmic reticulum and the Golgi apparatus, it further enters the cytoplasm. During the period, it is ubiquitinated and recruited TBK1 protein, then phosphorylated, and then combined with IRF3; then IRF3 is phosphorylated and enters the nucleus to induce the expression of IFNs, etc. In conclusion, it can enhance the body's immune ability and kill bacteria, viruses and other pathogens to a greater extent.

• Abbreviation:

  STING

• UniProt:

  Q86WV6

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant human STING fragment

• Target:

  NET; TMEM; TMEM173; ERIS; MITA; MPYS; NET23; SAVI; STING; hMITA; hSTING; Mediator of IRF3 activation; Stimulator of interferon genes protein; STING1; endoplasmic reticulum IFN stimulator; Endoplasmic reticulum interferon stimulator; FLJ38577; Mitochondrial mediator of IRF3 activation; N terminal methionine proline tyrosine serine plasma membrane tetraspanner; Stimulator of interferon genes; TM173; Transmembrane protein 173

• Clonality:

  Monoclonal, Recombinant

• Clone:

  A369

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC; IF

• Field of Research:

  Immunology; Signal Transduction; Epigenetics and Nuclear Signaling; Cancer

• Purification:

  Protein A purified

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:50

• Buffer:

  PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.

• Shipping Conditions:

  Ice bag

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  42 kDa

• Observed Molecular Weight:

  36 kDa

• Isotype:

  IgG, κ