SHP2-IN-31

SHP2-IN-31

• CAS Number: 2411321-35-0
• UNSPSC Description: SHP2-IN-31 is a SHP2 inhibitor, with IC50s of 13 nM (Wild-type SHP2), >10000 nM (SHP1), >10000 nM (SHP2 E76K) . SHP2-IN-31 inhibits pERK in a panel of tumor cells. SHP2-IN-31 inhibits tumor growth in RTK/KRAS-driven xenograft models[1].
• Target Antigen: ERK; SHP2
• Type: Reference compound
• Related Pathways: MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/shp2-in-31.html
• Smiles: N[C@H]1C2(CO[C@H]1C)CCN(C3=C(C(N(C4=C(C(Cl)=CC=C4)Cl)C(C)=N3)=O)C)CC2
• Molecular Weight: 437.36
• References & Citations: [1]James P. Stice, et al. Abstract P207: BBP-398, a potent, small molecule inhibitor of SHP2, enhances the response of established NSCLC xenografts to KRASG12C and mutEGFR inhibitors. Mol Cancer Ther (2021) 20 (12_Supplement): P207.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported