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SHP2-IN-31

CAT: 0931-T89411-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89411-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2411321-35-0
Target
Ras, Kras
Related Pathways
MAPK
Bioactivity
SHP2-IN-31 is an SHP2 inhibitor with an IC50 value of 13 nM (wild-type SHP2), >10000 nM (SHP1), and >10000 nM (SHP2 E76K) . This compound effectively inhibits pERK in a variety of tumor cells and suppresses tumor growth in xenograft models driven by RTK/KRAS.
Smiles
N[C@H]1C2(CCN(CC2)C3=C(C)C(=O)N(C(C)=N3)C4=C(Cl)C(Cl)=CC=C4)CO[C@H]1C
Molecular Formula
C21H26Cl2N4O2
Molecular Weight
437.36
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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