PF-07258669

• Description :

  PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM) . PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa[1].

• CAS Number :

  [2755890-53-8]

• UNSPSC :

  12352005

• Target :

  Melanocortin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pf-07258669.html

• Purity :

  98.44

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(N=C(N1)C(CC[C@]21CCN(C([C@H](C)C3=C(C=NC(OC)=C3)F)=O)C2)=C4)=C4C5=NC=CC=N5

• Molecular Formula :

  C25H27FN6O2

• Molecular Weight :

  462.52

• References & Citations :

  [1]Christopher Ryan BUTLER, et al. Spiro compounds as melanocortin 4 receptor antagonists and uses thereof. Patent. WO2021250541A1.|[2]Garnsey MR, et al., Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss. J Med Chem. 2023 Mar 9;66 (5) :3195-3211.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• Isoform :

  MC4R