PF-07258669

• Description:

  PF-07258669 is an orally active melanocortin-4 receptor (MC4R) antagonist that antagonizes MC4R with an IC50 of 13 nM (Ki=0.46 nM) . PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa[1].

• UNSPSC:

  12352005

• Target:

  Melanocortin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/pf-07258669.html

• Purity:

  98.44

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC (N=C (N1) C (CC[C@]21CCN (C ([C@H] (C) C3=C (C=NC (OC) =C3) F) =O) C2) =C4) =C4C5=NC=CC=N5

• Molecular Formula:

  C25H27FN6O2

• Molecular Weight:

  462.52

• References & Citations:

  [1]Christopher Ryan BUTLER, et al. Spiro compounds as melanocortin 4 receptor antagonists and uses thereof. Patent. WO2021250541A1.|[2]Garnsey MR, et al., Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss. J Med Chem. 2023 Mar 9;66 (5) :3195-3211.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• Isoform:

  MC4R

• CAS Number:

  2755890-53-8