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GPX4/CDK-IN-1

CAT: 0804-HY-163272Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163272Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPX4/CDK-IN-1 (Compound B9) is a dual inhibitor of GPX4 and CDK, with IC50 values of 542.5 nM, 191.2 nM and 68.1 nM for GPX4, CDK4 and CDK6, reapectively. GPX4/CDK-IN-1 shows strong cancer cell growth inhibition in vivo[1].
UNSPSC
12352005
Target
CDK; Glutathione Peroxidase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gpx4-cdk-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(/C1=C2NC3=C(C\2=N/OCCCNC(CCN4N=NC(COC5=C(C=C(C=C5)N(C(CCl)=O)C(C6=CC=CS6)C(NCCC7=CC=CC=C7)=O)Cl)=C4)=O)C=CC=C3)NC8=C1C=CC(OC)=C8
Molecular Formula
C48H45Cl2N9O7S
Molecular Weight
962.90
References & Citations
[1]Zhu J, et al. Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors. J Med Chem. 2024 Jan 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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