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CAIX/CDK-2-IN-1

CAT: 0804-HY-179022Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179022Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as lung cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Carbonic Anhydrase; Caspase; CDK; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
ClC1=CC=C(C2=NC(N=C(SCC(NC3=CC=C(S(=O)(N)=O)C=C3)=O)NC4=O)=C4C(C5=CC=CS5)=C2)C=C1
Molecular Formula
C25H18ClN5O4S3
Molecular Weight
584.09
References & Citations
[1]Abosalim HM, et al. Innovative design and synthesis of dual-acting hCA IX/CDK-2 inhibitors through hetero ring fused pyrimidine utilization for cutting-edge anticancer therapy: Zein nanoparticles for in vivo lung cancer treatment. Bioorg Chem. 2025 Oct 5;166:109057.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; CA IX; Caspase 3; Caspase 8; Caspase 9; CDK2

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