PF-04957325

CAT: 0804-HY-15426-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15426-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively.
CAS Number
[1305115-80-3]
UNSPSC
12352005
Hazard Statement
H242
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-04957325.html
Purity
99.55
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=C(N=NN2C[C@H]3CN(CC4=NC=CS4)CCO3)C2=NC(C(F)(F)F)=N1
Molecular Formula
C14H15F3N8OS
Molecular Weight
400.38
Precautions
H242
References & Citations
[1]Vang AG, et al. Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation. Front Pharmacol. 2016 Aug 23;7:259.|[2]Dong H, et al. Inhibition of breast cancer cell migration by activation of cAMP signaling. Breast Cancer Res Treat. 2015 Jul;152 (1) :17-28.|[3]Tsai LC, et al. Regulation of adrenal steroidogenesis by the high-affinity phosphodiesterase 8 family. Horm Metab Res. 2012 Sep;44 (10) :790-4.|[4]Shimizu-Albergine M, et al. cAMP-specific phosphodiesterases 8A and 8B, essential regulators of Leydig cell steroidogenesis. Mol Pharmacol. 2012 Apr;81 (4) :556-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-123474PF-1163B
HY-120004PF-06827443
HY-19999PF-CBP1
HY-163959-01PF-07853578
HY-124173PF-06815189
HY-120741-01PF-04822163
HY-153964PF-06478939
HY-18138-01PF-03382792
HY-128794PF-05150122
HY-117923PF-06465603

Alternative Products

CatalogName
BA8152-1PF-04957325
A21246-1PF-04957325 1mg
A21246-5PF-04957325 5mg
A21246-10PF-04957325 10mg
A21246-25PF-04957325 25mg
A21246-50PF-04957325 50mg
A21246-100PF-04957325 100mg
A21246-10mM-DPF-04957325 10mM * 1mL in DMSO
MBS579460PF-03084014 (PF-3084014)
5790/50PF 05175157

Popular Products