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PF-04822163

CAT: 0804-HY-120741-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120741-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-04822163 is an orally active, selective, and blood-brain barrier permeable PDE1 inhibitor with IC50 values of 2 nM, 2.4 nM, and 7 nM for PDE1A, PDE1B, and PDE1C respectively. PF-04822163 can be used in the research of attention deficit hyperactivity disorder or Parkinson's disease[1].
CAS Number
1798334-07-2
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-04822163.html
Solubility
10 mM in DMSO
Smiles
COC1=C(OC)C=CC2=C([C@H]3CCC4=C3C=C(Cl)C=C4)N=CN=C12
Molecular Formula
C19H17ClN2O2
Molecular Weight
340.80
References & Citations
[1]Humphrey J M, et al. Small-molecule phosphodiesterase probes: discovery of potent and selective CNS-penetrable quinazoline inhibitors of PDE1[J]. MedChemComm, 2014, 5 (9) : 1290-1296.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE11; PDE2; PDE3; PDE4; PDE5; PDE7; PDE9

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