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PF-07853578

CAT: 0804-HY-163959-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-163959-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-07853578 (Example 11) is a PNPLA3 degrader with an EC50 of 8 nM. PNPLA3 degrader-1 can be used in the study of cirrhosis and hepatocellular carcinoma[1].
CAS Number
3036158-98-9
UNSPSC
12352005
Target
PNPLA3
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pnpla3-degrader-1.html
Purity
99.08
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S1(N(CC[C@H]1C)[C@H]2CN(CC(F)(C2)F)C(OC3=CC=C(C=C3)Cl)=O)=O
Molecular Formula
C16H19ClF2N2O4S
Molecular Weight
408.85
References & Citations
[1]Christopher William Am Ende, et al. Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers. WO, WO2024084360A1. 2024-04-25
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
Phase 1

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