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(±) 12-HEPE

CAT: 0804-HY-117044A-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-117044A-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(±) 12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12 (S) -HEPE and 12 (R) -HEPE. The biological activity of (±) 12-HEPE is likely mediated by one of the individual isomers, most commonly the 12 (S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 μM) .
CAS Number
81187-21-5
Product Name Alternative
8-Nitrotryptanthrin
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/racemic-12-hepe.html
Smiles
CC/C=C\C/C=C\CC(O)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Karanian, et al. Inhibitory effects of n-6 and n-3 hydroxy fatty acids on thromboxane (U46619) -induced smooth muscle contraction. J. Pharmacol. Exp. Ther. 270 (3), 1105-1109 (1994) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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