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12 (S) -HEPE

CAT: 0804-HY-W747548-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-W747548-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
12 (S) -HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12 (S) -HEPE to 12 (S),20-diHEPE, whereas stimulated neutrophils produce 5 (S),12 (S) -HEPE via the 5-lipoxygenase pathway. The competitive action of 12 (S) -HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.
CAS Number
116180-17-7
UNSPSC
12352211
Hazard Statement
H225-H319
Target
Leukotriene Receptor; Lipoxygenase
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/12-s-hepe.html
Smiles
CC/C=C\C/C=C\C[C@H](O)/C=C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501
References & Citations
[1]von Schacky, et al. Platelet-neutrophil interactions. 12S,20- and 5S,12S-dihydroxyeicosapentaenoic acids: Two novel neutrophil metabolites from platelet-derived 12S-hydroxyeicosapentaenoic acid. J. Lipid Res. 31, 801-810 (1990) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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