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20-HEPE

CAT: 0804-HY-121888-01Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-121888-01Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.
CAS Number
116477-57-7
UNSPSC
12352211
Hazard Statement
H225-H319-H336
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/20-hepe.html
Smiles
OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501
References & Citations
[1]Harmon, et al. Oxygenation of ω-3 fatty acids by human cytochrome P450 4F3B: Effect on 20-hydroxyeicosatetraenoic acid production. Prostaglandins Leukot. Essent. Fatty Acids 75 (3), 169-177 (2006) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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