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(±) 12-HEPE

CAT: 0931-T35506-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T35506-01Size:25 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
81187-21-5
Target
Prostaglandin Receptor, Others
Related Pathways
Others, Immunology/Inflammation, GPCR/G Protein
Bioactivity
(±) 12-HEPE is produced by non-enzymatic oxidation of EPA, resulting in equal amounts of 12 (S) -HEPE and 12 (R) -HEPE. The biological activity of (±) 12-HEPE is likely mediated by one of the individual isomers, primarily the 12 (S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with an IC50 of 24 μM, similar to 12-HETE (IC50 = 25 μM), and both compounds also inhibit U46619-induced contraction of rat aorta with IC50 values between 8.6-8.8 μM. [1][2]
Smiles
CC\C=C/C\C=C/CC(O)\C=C\C=C/C\C=C/CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.457
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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