(±) 5-HEPE

CAT: 0804-HY-N7801Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-N7801Size:1 Each
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Description
(±) 5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5 (S) -HEPE and 5 (R) -HEPE. The biological activity of (±) 5-HEPE is likely mediated by one of the individual isomers, most commonly the 5 (S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
CAS Number
[83952-40-3]
UNSPSC
12352211
Hazard Statement
H225-H319
Target
Drug Isomer
Type
Natural Products
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/racemic-5-hepe.html
Smiles
CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(O)CCCC(O)=O
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501
References & Citations
[1]Powell, et al. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. J. Lipid Res. 36, 2590-2598 (1995) .
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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