(±) 5-HEPE

• Description :

  (±) 5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5 (S) -HEPE and 5 (R) -HEPE. The biological activity of (±) 5-HEPE is likely mediated by one of the individual isomers, most commonly the 5 (S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

• UNSPSC :

  12352211

• Hazard Statement :

  H225-H319

• Target :

  Drug Isomer

• Type :

  Natural Products

• Related Pathways :

  Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/racemic-5-hepe.html

• Smiles :

  CC/C=C\C/C=C\C/C=C\C/C=C\C=C\C(O)CCCC(O)=O

• Molecular Formula :

  C20H30O3

• Molecular Weight :

  318.45

• Precautions :

  P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P370+P378-P403+P235-P501

• References & Citations :

  [1]Powell, et al. Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils. J. Lipid Res. 36, 2590-2598 (1995) .

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [83952-40-3]