5-HEPE

• Description:

  5-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO) . 5 (S) -HEPE is an agonist of G protein-coupled receptor 119 (GPR119) . 5 (S) -HEPE increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5 (S) -HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5 (S) -HEPE are elevated in patients with hyperlipidemia.

• UNSPSC:

  12352211

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/5-hepe.html

• Smiles:

  CC/C=C\C/C=C\C/C=C\C/C=C\C=C\[C@@H] (O) CCCC (O) =O

• Molecular Formula:

  C20H30O3

• Molecular Weight:

  318.45

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Noguchi, et al. Action of ebselen as an antioxidant against lipid peroxidation. Biochem. Pharmacol. 44 (1), 39-44 (1992) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  92008-51-0