AC 253

• Description :

  AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM[1].

• UNSPSC :

  12352209

• Target :

  Amyloid-β

• Type :

  Peptides

• Related Pathways :

  Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/ac-253.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C=C1)=CC=C1C[C@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O

• Molecular Formula :

  C122H196N40O39

• Molecular Weight :

  2847.11

• References & Citations :

  [1]H A Coppock, et al. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem J. 1999 Feb 15;338 (Pt 1) (Pt 1) :15-22.|[2]Wen Fu, ET AL. Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J Biol Chem. 2012 May 25;287 (22) :18820-30.|[3]Jack H Jhamandas, et al. Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am J Pathol. 2011 Jan;178 (1) :140-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• CAS Number :

  [151804-79-4]