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AC 253

CAT: 0804-HY-P2285Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P2285Size:1 Each
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Description
AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM[1].
CAS Number
151804-79-4
UNSPSC
12352209
Target
Amyloid-β
Type
Peptides
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ac-253.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(N)=O)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CC(C)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@@H](NC(C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)C(N3[C@@H](CCC3)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(NCC(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N)=O)CC4=CC=C(C=C4)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C122H196N40O39
Molecular Weight
2847.11
References & Citations
[1]H A Coppock, et al. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem J. 1999 Feb 15;338 (Pt 1) (Pt 1) :15-22.|[2]Wen Fu, ET AL. Amyloid β (Aβ) peptide directly activates amylin-3 receptor subtype by triggering multiple intracellular signaling pathways. J Biol Chem. 2012 May 25;287 (22) :18820-30.|[3]Jack H Jhamandas, et al. Actions of β-amyloid protein on human neurons are expressed through the amylin receptor. Am J Pathol. 2011 Jan;178 (1) :140-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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