Anticancer agent 253

• Description:

  Anticancer agent 253 (Compound 26) has anti-cancer activity against breast cancer cells, with IC50s of 6 μM (MCF-7), 10 μM (MDA-MB-231) and 6.4 μM (4T1 cells) . Anticancer agent 253 arrests cell cycle and induces mitochondria-mediated apoptosis in cancer cells. Anticancer agent 253 inhibits Akt phosphorylation in human breast and prostate cancer[1].

• UNSPSC:

  12352005

• Target:

  Akt; Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PI3K/Akt/mTOR

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-253.html

• Smiles:

  O=C(/C(CN(C/1)CC2=CN(N=N2)CC3=CC=C(C=C3)F)=C/C4=C(C=CC=C4)F)C1=C\C5=C(C=CC=C5)F

• Molecular Formula:

  C29H23F3N4O

• Molecular Weight:

  500.51

• References & Citations:

  [1]Mandalapu D, et al. Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines. Bioorg Med Chem Lett. 2016 Sep 1;26 (17) :4223-32.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1983924-33-9]