(E) -JP-2-196 (TFA)

• Description:

  JP-2-196 (TFA) is a molecular glue handle that can bind to the E3-ubiquitin ligases (RNF126, LRSAM1, RNF40, MID2, and RNF14) in vitro. JP-2-196 (TFA) can be used to synthesize molecular glue degraders[1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Purity:

  97.89

• Smiles:

  OC (C (F) (F) F) =O.O=C (N1CCNCC1) /C=C/C (C2=CC=C (C=C2) OC) =O

• Molecular Formula:

  C17H19F3N2O5

• Molecular Weight:

  388.34

• References & Citations:

  [1]Toriki, E. S., et al., (2023) . Rational Chemical Design of Molecular Glue Degraders. ACS central science, 9 (5), 915–926.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  Store at room temperature, keep dry and cool

• Scientific Category:

  Reference compound2

• Clinical Information:

  No Development Reported

• CAS Number:

  3065021-33-9