Antitumor agent-155

• UNSPSC Description:

  Antitumor agent-155 (Compound 13) inhibits microtubule polymerization, induces autophagy and apoptosis. Antitumor agent-155 shows cytotoxicity against HCT116, A549, AGS, SK-MES-1 cells with IC50s of 0.227, 0.253, 0.574, 0.423 μM respectively[1].

• Target Antigen:

  Apoptosis; Autophagy; Microtubule/Tubulin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Cell Cycle/DNA Damage;Cytoskeleton

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/antitumor-agent-155.html

• Smiles:

  COC1=CC(/C(C(N2CCN(CC2)C3=CC=C(C=C3)C)=O)=C\C4=CC(O)=C(C=C4)OC)=CC(OC)=C1OC

• Molecular Weight:

  518.60

• References & Citations:

  [1]Zhang H, et al. Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells. Eur J Med Chem. 2024 Jun 5;272:116497.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4