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PSB-22269

CAT: 0804-HY-159920Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159920Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PSB-22269 is a GPR17 antagonist with a Ki value of 8.91 nM. PSB-22269 further demonstrated significant inhibitory effects in cAMP and G protein activation assays. Molecular docking studies revealed that the binding site of PSB-22269 contains positively charged arginine residues and a hydrophobic pocket. PSB-22269 provides a strategy to promote remyelination and holds promise for research in the field of multiple sclerosis[1].
UNSPSC
12352005
Target
Orphan Nuclear Receptor; Orphan Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Vitamin D Related/Nuclear Receptor
Field of Research
Neurological Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/psb-22269.html
Smiles
COC1=CC(C(O)=O)=C(NC(C2=CC=C(C3=C(C4=CC=CC(OC)=C4)C=CC=C3)O2)=O)C=C1
Molecular Formula
C26H21NO6
Molecular Weight
443.45
References & Citations
[1]Boshta NM, et al. Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17. J Med Chem. 2024 Nov 14;67 (21) :19365-19394.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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