PSB 0474

• Description:

  PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM[1]. PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis[2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; P2Y Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/psb-0474.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@H]([C@@H]1O)[C@@](N(C=CC2=O)C(N2CC(C3=CC=CC=C3)=O)=O)([H])O[C@@H]1CO[P](O[P](O)(O)=O)(O)=O

• Molecular Formula:

  C17H20N2O13P2

• Molecular Weight:

  522.29

• References & Citations:

  [1]Ali El-Tayeb, et al. Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J Med Chem. 2006 Nov 30;49 (24) :7076-87.|[2]Clara Quintas, et al. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014 Sep 3;11:141.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  P2Y6 Receptor

• CAS Number:

  917567-60-3