Ac-WLA-AMC

CAT: 0804-HY-123051-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-123051-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Ac-WLA-AMC is a specific 20S constitutive proteasome β5 fluorogenic substrate[1].

CAS Number

1104011-59-7

UNSPSC

12171500

Target

Proteasome

Type

Dye Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ac-wla-amc.html

Purity

99.79

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@@H](C(NC1=CC=C(C(O2)=C1)C(C)=CC2=O)=O)NC([C@H](CC(C)C)NC([C@H](CC3=CNC4=CC=CC=C34)NC(C)=O)=O)=O

Molecular Formula

C32H37N5O6

Molecular Weight

587.67

References & Citations

[1]Kim S, et al. Evaluation of Immunoproteasome-Specific Proteolytic Activity Using Fluorogenic Peptide Substrates. Immune Netw. 2022 Apr 15;22 (3) :e28.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Dye Reagents

Clinical Information

No Development Reported

Chemical Information

Ac-WLA-AMC

CAS Number	1104011-59-7
PubChem CID	137700559
IUPAC Name	(2S)-2-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-4-methyl-N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]pentanamide
Molecular Formula	C32H37N5O6
Molecular Weight	587.7
XLogP	3.3
Topological Polar Surface Area	158
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	11
Heavy Atom Count	43
Formal Charge	0
Complexity	1090

SMILES

CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)C

InChI

InChI=1S/C32H37N5O6/c1-17(2)12-26(37-32(42)27(35-20(5)38)14-21-16-33-25-9-7-6-8-24(21)25)31(41)34-19(4)30(40)36-22-10-11-23-18(3)13-29(39)43-28(23)15-22/h6-11,13,15-17,19,26-27,33H,12,14H2,1-5H3,(H,34,41)(H,35,38)(H,36,40)(H,37,42)/t19-,26-,27-/m0/s1

InChIKey

PIJMRHCPKXLMIS-DOYMOWJKSA-N

Chemical Structure

2D Structure

CAS: 1104011-59-7

CID: 137700559

Formula: C32H37N5O6

MW: 587.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	587.7
XLogP3	3.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	11
Exact Mass	587.27438392
Monoisotopic Mass	587.27438392
Topological Polar Surface Area	158 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	1090
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-P11213	Ac-RYQK (Ac) -AMC
HY-P11212	Ac-RHKK (Ac) -AMC
HY-P3364-01	Ac-QPKK (Ac) -AMC
HY-P11406	Ac-RSLK-AMC
HY-P10082	Ac-VETD-AMC
HY-P5378	Ac-KQKLR-AMC
HY-P4449	Ac-VRPR-AMC
HY-123052-01	Ac-PAL-AMC
HY-P2717-01	Ac-YVAD-AMC
HY-P10162	Ac-DMQD-AMC

Alternative Products

Catalog	Name
BA8290-1	Ac-WLA-AMC
sc-495760	(Ac-WLA) 2R110
T85587-01	Ac-QPKK (Ac) -AMC
GTR19144608-01	Ac-RYQK (Ac) -AMC
TP3791-01	Ac-RHKK (Ac) -AMC
BA4167-5.1	Ac-Lys-AMC
C8322-5	Ac-YEVD-AMC
4028557.0050	Ac-Met-AMC
I-1830.0050	Ac-Ala-AMC
T36342-01	Ac-LEHD-AMC

Ac-WLA-AMC

Chemical Information

Related Products

Alternative Products

Popular Products