BuChE-IN-10

• UNSPSC Description:

  BuChE-IN-10 (compound 7p) is an inhibitor of BuChE (eqBuChE IC50 = 4.68 nM, huBuChE IC50 = 9.12 nM). BuChE-IN-10 has anti-neuroinflammatory activity and exhibits high BBB permeability[1].

• Target Antigen:

  Cholinesterase (ChE)

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/buche-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(/C=C/C2=CC(OC(N3CCCCC3)=O)=CC=C2)OC(C)=CC1=O

• Molecular Weight:

  369.41

• References & Citations:

  [1]Chuanyu Yu, et al. Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Chuanyu Yu, et al. Novel anti-neuroinflammatory pyranone-carbamate derivatives as selective butyrylcholinesterase inhibitors for treating Alzheimer's disease. J Enzyme Inhib Med Chem. 2024, 39, 1.disease. J Enzyme Inhib Med Chem. 2024, 39, 1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported