BMS-191011

• Description :

  BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel) . BMS-191011 shows neuroprotective activities in rodent models of stroke[1].

• Product Name Alternative :

  BMS-A

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H413

• Target :

  Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/bms-191011.html

• Purity :

  99.56

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=CC(Cl)=CC=C3O

• Molecular Formula :

  C16H10ClF3N2O3

• Molecular Weight :

  370.71

• Precautions :

  H301, H413

• References & Citations :

  [1]Romine JL, et al. 3-[ (5-Chloro-2-hydroxyphenyl) methyl]-5-[4- (trifluoromethyl) phenyl ]-1,3,4-oxadiazol-2 (3H) -one, BMS-191011: opener of large-conductance Ca (2+) -activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50 (3) :528-42.|[2]Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34 (1) :150-2.|[3]Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel) . 2021 Dec 6;13 (23) :6144.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [202821-81-6]