MC-ND-18

• UNSPSC Description:

  MC-ND-18 is an ATTEC degrader of NLRP3 through autophagic mechanisms, with the DC50 of 125.5 nM in THP-1 cell. MC-ND-18 is composed of a NLRP3 ligand, linker and LC3 ligand[1].

• Target Antigen:

  ATTECs; NOD-like Receptor (NLR)

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Immunology/Inflammation;PROTAC

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/mc-nd-18.html

• Smiles:

  IC1=CC=C(C(/C(C2=O)=C/C3=CC(Br)=C(O)C(Br)=C3)=C1)N2CCOCCOCCOCCOC4=CC=C(S(NC(NC5=C6C(CCC6)=CC7=C5CCC7)=O)(=O)=O)C=C4

• Molecular Weight:

  1051.58

• References & Citations:

  [1]Kai Yin, et al. Discovery of autophagy-tethering compounds as potent NLRP3 degraders for IBD Immunotherapy. Eur J Med Chem. 2024 Sep 5:275:116581.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported