ND-2158

CAT: 0804-HY-120041Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120041Size:1 Each
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Description
ND-2158 is a competitive IRAK4 inhibitor, with the Ki of 1.3 nM. ND-2158 suppresses LPS-induced TNF production in human white blood cells, alleviated collagen-induced arthritis, and blocked gout formation in mouse models. ND-2158 has antitumor activity in vivo[1].
CAS Number
[1388896-07-8]
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nd-2158.html
Solubility
10 mM in DMSO
Smiles
O=C(N)[C@@H](O)C[C@H]1CCC2=C1C3=C(O[C@@H]4CC[C@@H](N5CCOCC5)CC4)N=CN=C3S2
Molecular Formula
C22H30N4O4S
Molecular Weight
446.56
References & Citations
[1]Kelly PN, et al. Selective interleukin-1 receptor-associated kinase 4 inhibitors for the treatment of autoimmune disorders and lymphoid malignancy. J Exp Med. 2015;212 (13) :2189-2201.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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