ND-L11B (TFA)

• Description:

  ND-L11B TFA is a potent degrader of nuclear receptor binding SET domain protein 2 (NSD2) and RE-IIBP, with the DC50 of 1.48 and 0.8 μM, the Dmax is closed to 80 %[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  O=C (COC1=CC (C2=NC=C (C (CN3C=NC4=C (N=CN=C34) N) =C2) N5C[C@] (N) (CCC5) CC (F) F) =CC=C1F) NCCCCCCCCCCCN.O=C (O) C (F) (F) F

• Molecular Formula:

  C39H52F6N10O4

• Molecular Weight:

  838.89

• References & Citations:

  [1]Linghao Hu, et al. Discovery of SET domain-binding primary alkylamine-tethered degraders for the simultaneous degradation of NSD2-long and RE-IIBP isoforms. Eur J Med Chem. 2025 Feb 5:283:117179.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported