(R)-ND-336

• UNSPSC Description:

  (R)-ND-336 is a potent and selective MMP-9 inhibitor with a Ki of 19 nM. (R)-ND-336 inhibits MMP-2 (Ki=127 nM) and MMP-14 (Ki=119 nM). (R)-ND-336 has the potential for diabetic foot ulcers (DFUs) research[1].

• Target Antigen:

  MMP

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/r-nd-336.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCC1=CC=C(OC2=CC=C(C=C2)S(C[C@@H]3SC3)(=O)=O)C=C1.Cl

• Molecular Weight:

  371.90

• References & Citations:

  [1]Trung T Nguyen, et al. Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. J Med Chem. 2018 Oct 11;61(19):8825-8837.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2252493-33-5