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ND-011992

CAT: 0804-HY-155107-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155107-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ND-011992 is a reversible, selective quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. ND-011992 inhibits respiratory complex I and bo3 oxidase in addition to bd-I and bd-II oxidases in E. coli strain BL21*Δcyo with the IC50 of 0.12, 2.47, 0.63 and 1.3 μM, respectively. ND-011992 can be used for tuberculosis study[1].
CAS Number
2446880-46-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Bacterial; Mitochondrial Metabolism
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/nd-011992.html
Purity
98.26
Solubility
DMSO : 40 mg/mL (ultrasonic; adjust pH to 4 with 1 M HCl)
Smiles
FC(F)(F)C(C=C1)=CC=C1OC(C=C2)=CC=C2NC3=NC=NC4=CC=CC=C43
Molecular Formula
C21H14F3N3O
Molecular Weight
381.35
Precautions
H302, H315, H319
References & Citations
[1]Kägi J, et al. Exploring ND-011992, a quinazoline-type inhibitor targeting quinone reductases and quinol oxidases. Sci Rep. 2023;13 (1) :12226. Published 2023 Jul 28. doi:10.1038/s41598-023-39430-w
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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