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(rac) -AR-13503

CAT: 0804-HY-125639-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-125639-01Size:5 mg
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Description
(rac) -AR-13503 ((rac) -AR-13324 M1 metabolite) is the isoform of AR-13503. AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice[1][2].
CAS Number
1254032-16-0
Product Name Alternative
(rac) -AR-13324 M1 metabolite
UNSPSC
12352005
Target
PKC; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rac-ar-13503.html
Purity
99.08
Solubility
1 M HCl : 25 mg/mL (ultrasonic) |DMSO : 40 mg/mL (ultrasonic; warming; adjust pH to 2 with 1 M HCl; heat to 60°C)
Smiles
O=C(C(CN)C1=CC=C(CO)C=C1)NC2=CC3=C(C=C2)C=NC=C3
Molecular Formula
C19H19N3O2
Molecular Weight
321.37
References & Citations
[1]Ding J, et al. ROCK/PKC inhibitor AR-13503 inhibits angiogenesis and protects the barrier function of retinal pigment epithelium[J]. Investigative Ophthalmology & Visual Science, 2018, 59 (9) : 205-205. |[2]Carbajal K, et al. AR-13503 Enhances the efficacy of aflibercept in a mouse model of proliferative diabetic retinopathy[J]. Investigative Ophthalmology & Visual Science, 2018, 59 (9) : 200-200.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

AR-13324 M1 metabolite
CAS Number1254032-16-0
PubChem CID134128281
IUPAC Name(2S)-3-amino-2-[4-(hydroxymethyl)phenyl]-N-isoquinolin-6-ylpropanamide
Molecular FormulaC19H19N3O2
Molecular Weight321.4
XLogP1.6
Topological Polar Surface Area88.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity409
SMILES
C1=CC(=CC=C1CO)[C@@H](CN)C(=O)NC2=CC3=C(C=C2)C=NC=C3
InChI
InChI=1S/C19H19N3O2/c20-10-18(14-3-1-13(12-23)2-4-14)19(24)22-17-6-5-16-11-21-8-7-15(16)9-17/h1-9,11,18,23H,10,12,20H2,(H,22,24)/t18-/m1/s1
InChIKey
LTXBFJFJUIJOQE-GOSISDBHSA-N
Chemical Structure
2D Structure
2D structure of AR-13324 M1 metabolite
CAS: 1254032-16-0
CID: 134128281
Formula: C19H19N3O2
MW: 321.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight321.4
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass321.147726857
Monoisotopic Mass321.147726857
Topological Polar Surface Area88.2 Ų
Heavy Atom Count24
Formal Charge0
Complexity409
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
CS-O-63799Rac-AR-13324 M1 metabolite
CS-O-64465Rac-AR-13324 M1 Metabolite-d6
FPD79967-01Rac- (3'aR,6'aR) -1-[ (tert-Butoxy) carbonyl]-hexahydrospiro[azetidine-3,1'-furo[3,4-c]pyrrole]-3'A-carboxylic acid
XLD27022-01Rac- (3'aR,6'aS) -Hexahydrospiro[cyclobutane-1,3'-furo[3,4-b]pyrrole] hydrochloride
APD14414-01Rac-1-tert-Butyl 3'A-methyl (3'aR,6'aR) -hexahydrospiro[azetidine-3,1'-furo[3,4-c]pyrrole]-1,3'A-dicarboxylate
FPD79863-01Rac- (3'aR,6'aR) -1-[ (tert-Butoxy) carbonyl]-5'-{[ (9H-fluoren-9-yl) methoxy]carbonyl}-hexahydrospiro[azetidine-3,1'-furo[3,4-c]pyrrole]- 3'A-carboxylic acid
N0570-50BRac Nebivolol, Hydrochloride ((aR, a’R,2R,2’S) -rel-a, a’-[Iminobis (methylene) ]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol], a, a’- (Iminodimethylene) bis[6-fluoro-2-chromanmethanol] Hydrochloride , Lobivon, Nebilet, Nebilox, R-67555, )
MBS6034133-01rac Nebivolol, Hydrochloride ((aR,a'R,2R,2'S)-rel-a,a'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol], a,a'-(Iminodimethylene)bis[6-fluoro-2-chromanmethanol] Hydrochloride, Lobivon, Nebilet, Nebilox, R-67555,)
T71120-01AR-13503
GTR19235600-01AR/AR-V7-IN-1

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