4'-Hydroxychalcone

CAT: 0804-HY-N7056-01Size: 5 gDry Ice: NoHazardous: No
CAT#:0804-HY-N7056-01Size:5 g
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Description
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].
CAS Number
[2657-25-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Oxidative Phosphorylation; Proteasome
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/4-hydroxychalcone.html
Purity
99.66
Solubility
DMSO : 233.33 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(O)C=C1)/C=C/C2=CC=CC=C2
Molecular Formula
C15H12O2
Molecular Weight
224.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7 (4) :245-54.|[2]Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7 (2) .|[3]Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82 (6) :620-31.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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