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4-Hydroxychalcone (Standard)

CAT: 0804-HY-107818R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107818R-01Size:10 mg
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Description
4-Hydroxychalcone (Standard) is the analytical standard of 4-Hydroxychalcone. This product is intended for research and analytical applications. 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
CAS Number
[20426-12-4]
UNSPSC
12352100
Hazard Statement
H315-H319-H335-H401-H411
Target
NF-κB; Reference Standards
Related Pathways
NF-κB; Others
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Smiles
O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2
Molecular Formula
C15H12O2
Molecular Weight
224.25
Precautions
P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362-P391-P403+P233-P405-P501
References & Citations
[1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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