4-Hydroxychalcone
CAT:
804-HY-107818-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
4-Hydroxychalcone
- CAS Number: 20426-12-4
- UNSPSC Description: 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
- Target Antigen: NF-κB
- Type: Natural Products
- Related Pathways: NF-κB
- Applications: Neuroscience-Neuromodulation
- Field of Research: Inflammation/Immunology; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/4-hydroxychalcone-1.html
- Purity: 99.73
- Solubility: DMSO : ≥ 250 mg/mL
- Smiles: O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2
- Molecular Weight: 224.25
- References & Citations: [1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691(1-3):125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, protect from light)
- Clinical Information: No Development Reported