4-Hydroxychalcone

• Description :

  4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  NF-κB

• Type :

  Natural Products

• Related Pathways :

  NF-κB

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxychalcone-1.html

• Purity :

  99.29

• Solubility :

  DMSO : ≥ 250 mg/mL

• Smiles :

  O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2

• Molecular Formula :

  C15H12O2

• Molecular Weight :

  224.25

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• CAS Number :

  [20426-12-4]