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4-Hydroxychalcone

CAT: 0804-HY-107818-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107818-01Size:100 mg
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Description
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].
CAS Number
[20426-12-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
NF-κB
Type
Natural Products
Related Pathways
NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/4-hydroxychalcone-1.html
Purity
99.29
Solubility
DMSO : ≥ 250 mg/mL
Smiles
O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2
Molecular Formula
C15H12O2
Molecular Weight
224.25
Precautions
H302, H315, H319, H335
References & Citations
[1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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