4-Hydroxychalcone

• Description:

  4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity[1]. 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice[2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  NF-κB

• Type:

  Natural Products

• Related Pathways:

  NF-κB

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Inflammation/Immunology; Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/4-hydroxychalcone-1.html

• Purity:

  99.29

• Solubility:

  DMSO : ≥ 250 mg/mL

• Smiles:

  O=C(C1=CC=CC=C1)/C=C/C2=CC=C(O)C=C2

• Molecular Formula:

  C15H12O2

• Molecular Weight:

  224.25

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Varinska L, et al. Anti-angiogenic activity of the flavonoid precursor 4-hydroxychalcone. Eur J Pharmacol. 2012 Sep 15;691 (1-3) :125-33.|[2]Qu Q, et al. 4-Hydroxychalcone attenuates hyperaldosteronism, inflammation, and renal injury in cryptochrome-null mice. Biomed Res Int. 2014;2014:603415.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [20426-12-4]