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DC-TEADin02

CAT: 0804-HY-126621-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-126621-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DC-TEADin02 is a potent TEAD autopalmitoylation inhibitor. DC-TEADin02 has TEAD autopalmitoylation inhibitory with the IC50 value of 197 nM. DC-TEADin02 can be used for the research of development, regeneration and tissue homeostasis[1].
CAS Number
2380228-45-3
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dc-teadin02.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C=CS(=O)(NC1=CC=C(CC2=CC=C3C=CC=CC3=C2)C=C1)=O
Molecular Formula
C19H17NO2S
Molecular Weight
323.41
References & Citations
[1]Wenchao Lu, et al. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. Eur J Med Chem. 2019 Dec 15;184:111767.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

DC-TEADin02
CAS Number2380228-45-3
PubChem CID155527561
IUPAC NameN-[4-(naphthalen-2-ylmethyl)phenyl]ethenesulfonamide
Molecular FormulaC19H17NO2S
Molecular Weight323.4
XLogP4.5
Topological Polar Surface Area54.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity488
SMILES
C=CS(=O)(=O)NC1=CC=C(C=C1)CC2=CC3=CC=CC=C3C=C2
InChI
InChI=1S/C19H17NO2S/c1-2-23(21,22)20-19-11-8-15(9-12-19)13-16-7-10-17-5-3-4-6-18(17)14-16/h2-12,14,20H,1,13H2
InChIKey
IUZGUIPYVGPQFT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of DC-TEADin02
CAS: 2380228-45-3
CID: 155527561
Formula: C19H17NO2S
MW: 323.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight323.4
XLogP34.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass323.09799996
Monoisotopic Mass323.09799996
Topological Polar Surface Area54.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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