DC-S238

• Description:

  DC-S238 is an orally active and highly selective histone methyltransferase SET7 (SETD7) inhibitor (IC50=4.88 μM) . DC-S238 is promising for research of cancer, diabetes and inflammatory diseases[1].

• UNSPSC:

  12352005

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Field of Research:

  Cancer; Metabolic Disease; Inflammation/Immunology

• Smiles:

  O=C(OC)C1=C(SC(C(NC2=CC=CC([N+]([O-])=O)=C2)=O)=C1C)N

• Molecular Formula:

  C14H13N3O5S

• Molecular Weight:

  335.34

• References & Citations:

  [1]Meng F, et al. Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening. J Med Chem. 2015 Oct 22;58 (20) :8166-81.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  SETD7/KMT7

• CAS Number:

  [832109-48-5]