DC-TEAD3in03

• Description:

  DC-TEAD3in03 is a subtype-selective and covalent TEAD3 inhibitor with an IC50 of 0.16 μM. DC-TEAD3in03 exhibits the inhibitory activity on TEAD1/2/4 reduced by more than 100 times. DC-TEAD3in03 has the IC50 for TEAD3 of 1.15 μM in the GAL4-TEAD reporter gene experiment in cells, and it does not interfere with the β-catenin pathway. DC-TEAD3in03 reduces the growth rate of the zebrafish tail fin. DC-TEAD3in03 can be used to study the proportional growth of appendages in vertebrates[1].

• UNSPSC:

  12352005

• Target:

  YAP

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C(C=C)N1CN(CCCOCC2=CC=CC=C2)CCC1

• Molecular Formula:

  C17H24N2O2

• Molecular Weight:

  288.38

• References & Citations:

  [1]Lu T, et al. Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3. Acta Pharm Sin B. 2021 Oct;11 (10) :3206-3219.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TEAD