PROTAC EGFR degrader 9

PROTAC EGFR degrader 9

• CAS Number: 2992670-33-2
• UNSPSC Description: PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. PROTAC EGFR degrader 9 exhibits a DC50 of 10.2 nM and a Kd of 240.2 nM against EGFRL858R/T790M/C797S. PROTAC EGFR degrader 9 exhibits potent degradation activity against various EGFR mutants, while sparing the EGFRWT. (Blue: CRBN ligand (HY-A0003), Black: linker (HY-161613); Pink: EGFR inhibitor (HY-161537))[1].
• Target Antigen: Apoptosis; EGFR; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-egfr-degrader-9.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(CCCCCCN1CCN(C2=CC=C(NC3=NC=C(C(C4=CN(C5=CC=CC=C54)S(=O)(CC)=O)=N3)C(F)(F)F)C=C2)CC1)NC6=CC=CC7=C6CN(C7=O)C8C(NC(CC8)=O)=O
• Molecular Weight: 899.98
• References & Citations: [1]Yasheng Zhu, et al. Design, Synthesis, and Biological Evaluation of Novel EGFR PROTACs Targeting C797S Mutation. J Med Chem. 2024 May 9;67(9):7283-7300.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported