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PF-06426779

CAT: 0804-HY-123854-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123854-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-06426779 is a potent and selective inhibitor of interleukin 1 receptor associated kinase 4 (IRAK4), with an IC50 of 0.3 nM[1].
CAS Number
1817628-40-2
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-06426779.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC2=C(C(OC[C@H]([C@H](C)[C@@H]3F)NC3=O)=NC=C2)C=C1OC)N
Molecular Formula
C17H18FN3O4
Molecular Weight
347.34
References & Citations
[1]Lee KL, et, al. Discovery of Clinical Candidate 1-{[ (2S,3S,4S) -3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design. J Med Chem. 2017 Jul 13; 60 (13) : 5521-5542.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4

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