MK-2461

• Description :

  MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM) . MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM) . MK-2461 can be used for the study of cancer, such as gastric cancer[1].

• CAS Number :

  [917879-39-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H317, H319

• Target :

  C-Met/HGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/MK-2461.html

• Concentration :

  10mM

• Purity :

  99.28

• Solubility :

  DMSO : ≥ 31 mg/mL

• Smiles :

  O=S(N(C)C[C@H]1OCCOC1)(NC2=CC=C3C=CC(C(C(C3=C2)=O)=C4)=NC=C4C5=CN(N=C5)C)=O

• Molecular Formula :

  C24H25N5O5S

• Molecular Weight :

  495.55

• Precautions :

  H317, H319

• References & Citations :

  [1]Pan BS, et al. MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor. Cancer Res. 2010 Feb 15;70 (4) :1524-33.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Citation 01 :

  Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|J Cell Mol Med. 2025 Mar;29 (5) :e70486.