MK-7725

CAT: 0804-HY-18612Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18612Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-7725 is a selective, orally active, and blood-brain barrier-permeable agonist of the subtype 3 of the frog skin peptide receptor (BRS-3) . MK-7725 has a high affinity for the human BRS-3 (hBRS-3), with an IC50 of 3 nM, and its functional activity in the mouse-derived BRS-3 (mBRS-3) model with an EC50 of 22 nM (105% agonistic) . MK-7725 significantly reduces the body weight of obese rats and obese dogs. MK-7725 can be used for the treatment of obesity[1].
CAS Number
[1034152-93-6]
UNSPSC
12352005
Target
Bombesin Receptor
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=S(N1C2=C(C3=NOC(C(C)(O)C)=N3)C=CC=C2NC4=NC(C(F)(F)F)=CC=C4C1)(C5=CC=C(OC(F)(F)F)C=C5)=O
Molecular Formula
C25H19F6N5O5S
Molecular Weight
615.50
References & Citations
[1]Chobanian HR, et al. Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med Chem Lett. 2012 Jan 21;3 (3) :252-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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