MK-2461

• CAS Number :

  917879-39-1

• SKU :

  C17058-10mg

• Target :

  C-Met

• Applications :

  Protein Tyrosine Kinase

• Smiles :

  CN1C=C (C=N1) C2=CC3=C (C=CC4=C (C3=O) C=C (C=C4) NS (=O) (=O) N (C) CC5COCCO5) N=C2

• Molecular Formula :

  C24H25N5O5S

• Additionnal Information :

  MK-2461 is a potent, multi-targeted inhibitor for c-Met (WT/mutants) with IC50 of 0.4-2.5 nM, less potent to Ron, Flt1; 8- to 30-fold greater selectivity of c-Met targets versus FGFR1, FGFR2, FGFR3, PDGFRβ, KDR, Flt3, Flt4, TrkA, and TrkB. Phase 1/2.

• Storage Conditions :

  2 years -80 in solvent