MK-0557

• Description :

  MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  Neuropeptide Y Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/MK-0557.html

• Concentration :

  10mM

• Purity :

  99.80

• Solubility :

  DMSO : 175 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

• Smiles :

  O=C([C@H]1CC[C@@](C2=C3C=CN=C2)(OC3=O)CC1)NC4=NN(C5=CC=CC=C5F)C=C4

• Molecular Formula :

  C22H19FN4O3

• Molecular Weight :

  406.41

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Fichtner M, et al. Discovery and evaluation of spirocyclic derivatives as antagonists of the neuropeptide Y5 receptor. Bioorg Med Chem Lett. 2012 Apr 15;22 (8) :2738-43.|[2]Erondu N, et al. Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults. Cell Metab. 2006 Oct;4 (4) :275-82.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 3

• Isoform :

  NPY Y5 receptor

• CAS Number :

  [328232-95-7]