LASSBio-1632

CAT: 0804-HY-131340Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-131340Size:1 Each
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Description
LASSBio-1632 is a new anti-asthmatic lead candidate associated with selective inhibition of PDE4A and PDE4D isoenzymes and blockade of airway hyper-reactivity (AHR) and TNF-α production in the lung tissue. LASSBio-1632 (7j) displays high experimental BBB permeability across BBB through passive diffusion[1].
CAS Number
[3029936-02-2]
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lassbio-1632.html
Solubility
10 mM in DMSO
Smiles
CC1=CC2=C(C=C1S(N(/N=C/C3=CC=C(C(OC)=C3)OC)C)(=O)=O)OCO2
Molecular Formula
C18H20N2O6S
Molecular Weight
392.43
References & Citations
[1]Isabelle Karine da Costa Nunes, et al. Discovery of sulfonyl hydrazone derivative as a new selective PDE4A and PDE4D inhibitor by lead-optimization approach on the prototype LASSBio-448: In vitro and in vivo preclinical studies. Eur J Med Chem. 2020 Jul 18;204:112492.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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